ZK98296
\zˌɛdkˈe͡ɪ nˈa͡ɪntiˈe͡ɪt θˈa͡ʊzənd tˈuːhˈʌndɹədən nˈa͡ɪntisˈɪks], \zˌɛdkˈeɪ nˈaɪntiˈeɪt θˈaʊzənd tˈuːhˈʌndɹədən nˈaɪntisˈɪks], \z_ˌɛ_d_k_ˈeɪ n_ˈaɪ_n_t_i__ˈeɪ_t θ_ˈaʊ_z_ə_n_d_ t_ˈuː_h_ˈʌ_n_d_ɹ_ə_d_ə_n n_ˈaɪ_n_t_i_s_ˈɪ_k_s]\
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A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.