X LINKED BULBO SPINAL ATROPHIES
\ˈɛks lˈɪŋkt bˈʌlbə͡ʊ spˈa͡ɪnə͡l ˈatɹəfɪz], \ˈɛks lˈɪŋkt bˈʌlbəʊ spˈaɪnəl ˈatɹəfɪz], \ˈɛ_k_s l_ˈɪ_ŋ_k_t b_ˈʌ_l_b_əʊ s_p_ˈaɪ_n_əl ˈa_t_ɹ_ə_f_ɪ_z]\
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A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.