VOLCANIC ROCK

\vɒlkˈanɪk ɹˈɒk], \vɒlkˈanɪk ɹˈɒk], \v_ɒ_l_k_ˈa_n_ɪ_k ɹ_ˈɒ_k]\
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2006 - WordNet 3.0
By Princeton University
 
2011 - English Dictionary Database
By DataStellar Co., Ltd

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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