VNTR SEQUENCES
\vˌiːˌɛntˌiːˈɑː sˈiːkwənsɪz], \vˌiːˌɛntˌiːˈɑː sˈiːkwənsɪz], \v_ˌiː__ˌɛ_n_t_ˌiː__ˈɑː s_ˈiː_k_w_ə_n_s_ɪ_z]\
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Tandem arrays of moderately repetitive (5-50 repeats) short (10-60 bases) DNA sequences found dispersed throughout the genome and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit. Minisatellite repeats are often called variable number of tandem repeats.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.