VARICELLA ENCEPHALITIS
\vˌaɹa͡ɪsˈɛləɹ ɛnsˌɛfɐlˈa͡ɪtɪs], \vˌaɹaɪsˈɛləɹ ɛnsˌɛfɐlˈaɪtɪs], \v_ˌa_ɹ_aɪ_s_ˈɛ_l_ə_ɹ ɛ_n_s_ˌɛ_f_ɐ_l_ˈaɪ_t_ɪ_s]\
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Inflammation of brain tissue caused by infection with the varicella-zoster virus (HERPESVIRUS 3, HUMAN). This condition is associated with immunocompromised states, including the ACQUIRED IMMUNODEFICIENCY SYNDROME. Pathologically, the virus tends to induce a vasculopathy and infect oligodendrocytes and ependymal cells, leading to CEREBRAL INFARCTION, multifocal regions of demyelination, and periventricular necrosis. Manifestations of varicella encephalitis usually occur 5-7 days after onset of HERPES ZOSTER and include HEADACHE; VOMITING; lethargy; focal neurologic deficits; FEVER; and COMA. (From Joynt, Clinical Neurology, 1996, Ch 26, pp29-32; Hum Pathol 1996 Sep;27 (9):927-38)
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.