V ERBA ONCOGENES
\vˈiː ˈɜːb ɐ ˈɒnkə͡ʊd͡ʒˌiːnz], \vˈiː ˈɜːb ɐ ˈɒnkəʊdʒˌiːnz], \v_ˈiː_ ˈɜː_b ɐ ˈɒ_n_k_əʊ_dʒ_ˌiː_n_z]\
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Retrovirus-associated DNA sequences (ERYTHROBLASTOSIS VIRUS, AVIAN, hence erbA) originally isolated from the avian erythroblastosis virus. The c-erbA proto-oncogene encodes the thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA proto-oncogenes have been identified, erbA-alpha and erbA-beta, each giving rise to at least two proteins. erbA-alpha is located at 17q21 on the long arm of chromosome 17. erbA-beta is located at 3p24 on the short arm of chromosome 3. The v-erbA oncogene potentiates cell transformation through inhibition of spontaneous differentiation of cells already transformed by the v-erbB gene and eliminates growth requirements of transformed erythroblasts.
By DataStellar Co., Ltd
Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.