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Definitions of v fms Protein

  1. Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus ( SM- FeSV). The oncogene protein v- fms lacks sequences, which, in the highly homologous proto- oncogene protein c- fms ( CSF- 1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v- fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120( v- fms) is post- translationally modified to generate gp140( v- fms).
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