\jˈuː tˈɛn θˈa͡ʊzənd ˈe͡ɪthˈʌndɹədən fˈɪftiˈe͡ɪt], \jˈuː tˈɛn θˈaʊzənd ˈeɪthˈʌndɹədən fˈɪftiˈeɪt], \j_ˈuː t_ˈɛ_n θ_ˈaʊ_z_ə_n_d_ ˈeɪ_t_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɪ_f_t_i__ˈeɪ_t]\
Definitions of U 10858
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A potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure. It is given by mouth in the treatment of severe hypertension unresponsive to other therapy. It is also used topically in the treatment of male-pattern baldness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
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- Malignant lymphoma in which neoplastic cells diffusely infiltrate the entire lymph node without any definite organized Patients whose lymphomas present a diffuse pattern generally have more unfavorable survival outlook than those presenting with follicular or nodular pattern.