TUMORIGENICITY TESTS
\tjˌuːməɹa͡ɪd͡ʒnˈɪsɪti tˈɛsts], \tjˌuːməɹaɪdʒnˈɪsɪti tˈɛsts], \t_j_ˌuː_m_ə_ɹ_aɪ_dʒ_n_ˈɪ_s_ɪ_t_i t_ˈɛ_s_t_s]\
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Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.