TUBEROUS SCLEROSIS
\tjˈuːbəɹəs skləɹˈə͡ʊsɪs], \tjˈuːbəɹəs skləɹˈəʊsɪs], \t_j_ˈuː_b_ə_ɹ_ə_s s_k_l_ə_ɹ_ˈəʊ_s_ɪ_s]\
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An autosomal dominant disorder which is generally classified as a phacomatosis. Pathologically, the condition is characterized by glial cell tumors which arise in the cerebral hemispheres and retina. There is an increased incidence of benign rhabdomyomas of the heart and angiomyolipomas of kidney, liver, lungs, thyroid, and testes. Clinical manifestations include MENTAL RETARDATION; adenoma sebaceum of the face (actually angiofibromas); EPILEPSY; SPASMS; INFANTILE; Shagreen patches on the trunk; and subungual fibromas. (From Adams et al., Principles of Neurology, 6th ed, p1011)
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Collagen Induced Arthritis
- ARTHRITIS that is induced in experimental animals. Immunological and infectious agents can be used to develop models. These methods include injections of stimulators the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.