TRYPSIN INHIBITOR, KUNITZ, PANCREATIC
\tɹˈɪpsɪn ɪnhˈɪbɪtə], \tɹˈɪpsɪn ɪnhˈɪbɪtə], \t_ɹ_ˈɪ_p_s_ɪ_n ɪ_n_h_ˈɪ_b_ɪ_t_ə]\
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A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including chymotrypsin, kallikrein, plasmin, and trypsin. It is used in the treatment of hemorrhage associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with extracorporeal circulation. (Reynolds JEF (Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
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