TRIIODOTHYRONINE RECEPTORS
\tɹˈa͡ɪɪˌɒdəθˌɪɹənˌa͡ɪn ɹɪsˈɛptəz], \tɹˈaɪɪˌɒdəθˌɪɹənˌaɪn ɹɪsˈɛptəz], \t_ɹ_ˈaɪ_ɪ__ˌɒ_d_ə_θ_ˌɪ_ɹ_ə_n_ˌaɪ_n ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erbA, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erbA proteins act as growth suppressors. The c-erbA proteins are encoded by at least two genes, c-erbA alpha and c-erbA beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes THYROID HORMONE RESISTANCE SYNDROME.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.