\tˈɒpɔ͡ɪsˌə͡ʊmɹe͡ɪz ɹˌə͡ʊmən fˈɔː], \tˈɒpɔɪsˌəʊmɹeɪz ɹˌəʊmən fˈɔː], \t_ˈɒ_p_ɔɪ_s_ˌəʊ_m_ɹ_eɪ_z ɹ_ˌəʊ_m_ə_n_ f_ˈɔː]\
Definitions of TOPOISOMERASE IV
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A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
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- A combination alginic acid, obtained from seaweed and copper; used in the anemias of leprosy, cancer, etc.