\tˈɒpɔ͡ɪsˌə͡ʊmɹe͡ɪz ˈa͡ɪ], \tˈɒpɔɪsˌəʊmɹeɪz ˈaɪ], \t_ˈɒ_p_ɔɪ_s_ˌəʊ_m_ɹ_eɪ_z ˈaɪ]\
Definitions of TOPOISOMERASE I
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DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
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