THIAMINE DEFICIENCIES
\θˈa͡ɪəmˌa͡ɪn dɪfˈɪʃənsɪz], \θˈaɪəmˌaɪn dɪfˈɪʃənsɪz], \θ_ˈaɪ_ə_m_ˌaɪ_n d_ɪ_f_ˈɪ_ʃ_ə_n_s_ɪ_z]\
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A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.