THERAPY RELATED CANCERS
\θˈɛɹəpi ɹɪlˈe͡ɪtɪd kˈansəz], \θˈɛɹəpi ɹɪlˈeɪtɪd kˈansəz], \θ_ˈɛ_ɹ_ə_p_i ɹ_ɪ_l_ˈeɪ_t_ɪ_d k_ˈa_n_s_ə_z]\
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Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.