TGF ALPHA RECEPTOR
\tˌiːd͡ʒˌiːˈɛf ˈalfə ɹɪsˈɛptə], \tˌiːdʒˌiːˈɛf ˈalfə ɹɪsˈɛptə], \t_ˌiː_dʒ_ˌiː__ˈɛ_f ˈa_l_f_ə ɹ_ɪ_s_ˈɛ_p_t_ə]\
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A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell. EC 2.7.11.-.
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