TERMINATION CODON
\tˌɜːmɪnˈe͡ɪʃən kˈɒdɒn], \tˌɜːmɪnˈeɪʃən kˈɒdɒn], \t_ˌɜː_m_ɪ_n_ˈeɪ_ʃ_ə_n k_ˈɒ_d_ɒ_n]\
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Any codon that signals the termination of genetic translation (TRANSLATION, GENETIC). PEPTIDE TERMINATION FACTORS bind to the stop codon and trigger the hydrolysis of the aminoacyl bond connecting the completed polypeptide to the tRNA. Terminator codons do not specify amino acids.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.