TAUOPATHIES
\tɔːˈɒpəθɪz], \tɔːˈɒpəθɪz], \t_ɔː_ˈɒ_p_ə_θ_ɪ_z]\
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Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE, DEMENTIA, PARKINSONIAN DISORDERS, progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE), and corticobasal degeneration.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.