\tˌapɪˈə͡ʊkə plˈant], \tˌapɪˈə‍ʊkə plˈant], \t_ˌa_p_ɪ__ˈəʊ_k_ə p_l_ˈa_n_t]\
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2006 - WordNet 3.0
By Princeton University
2011 - English Dictionary Database
By DataStellar Co., Ltd

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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