TANGIER HEREDITARY NEUROPATHIES
\tˈaŋɪə hɪɹˈɛdɪtəɹi njuːɹˈɒpəθɪz], \tˈaŋɪə hɪɹˈɛdɪtəɹi njuːɹˈɒpəθɪz], \t_ˈa_ŋ_ɪ__ə h_ɪ_ɹ_ˈɛ_d_ɪ_t_ə_ɹ_i n_j_uː_ɹ_ˈɒ_p_ə_θ_ɪ_z]\
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A rare autosomal recessive familial disorder of cholesterol metabolism, characterized by extremely low HDL-cholesterol, reduced total cholesterol, and increased triglyceride levels in serum. Clinical features include the onset before age 20 years of HEPATOMEGALY; SPLENOMEGALY; the deposition of cholesterol in each TONSIL (creating a yellow-orange appearance); and RETINITIS PIGMENTOSA. A sensorimotor or distal sensory POLYNEUROPATHY occurs in approximately 50% of affected individuals. The condition is associated with decreased synthesis and increased catabolism of APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II, and a defect in cellular signaling and mobilization of lipids. (From Nat Genet 1998 Sep;20 (1):96-8; Adams et al., Principles of Neurology, 6th ed, pp1347-8; Menkes, Textbook of Child Neurology, 5th ed, p118)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
Nearby Words
- tangie
- tangier
- tangier disease
- tangier disease neuropathies
- tangier disease neuropathy
- Tangier Hereditary Neuropathies
- tangier hereditary neuropathy
- tangier pea
- tangier peavine
- tangiers
- tanginess