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Definitions of T Cell Growth Factor Receptors

  1. Receptors present on activated T- and B- cells as a complex consisting of a 55 kD peptide, which reacts with the anti- Tac monoclonal antibody, and a 75 kD non- Tac interleukin- 2- binding peptide. The receptor is present in two forms, one with a very high affinity and the other with low affinity for IL- 2. The high- affinity form appears to mediate exclusively the growth- promoting response to IL- 2. The receptor is present in large numbers on resting HUMAN T- LYMPHOTROPIC VIRUS 1 leukemia cells, but not on normal resting cells.
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