SURFACE CD4 RECEPTOR
\sˈɜːfɪs sˌiːdˈiː fˈɔː ɹɪsˈɛptə], \sˈɜːfɪs sˌiːdˈiː fˈɔː ɹɪsˈɛptə], \s_ˈɜː_f_ɪ_s s_ˌiː_d_ˈiː f_ˈɔː ɹ_ɪ_s_ˈɛ_p_t_ə]\
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55-kD Glycoproteins originally defined as differentiation antigens on T-lymphocytes, but also found on other cells including monocytes/macrophages. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MHC (Major Histocompatibility Complex) Class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as HIV receptors, binding directly to the envelope protein gp120 on HIV.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.