SUPPLEMENTAL

\sˌʌplɪmˈɛntə͡l], \sˌʌplɪmˈɛntə‍l], \s_ˌʌ_p_l_ɪ_m_ˈɛ_n_t_əl]\
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1919 - The Winston Simplified Dictionary
By William Dodge Lewis, Edgar Arthur Singer
 
1920 - A practical medical dictionary.
By Stedman, Thomas Lathrop
 
1919 - The Concise Standard Dictionary of the English Language
By James Champlin Fernald

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Sporadic Retinoblastoma

  • A malignant arising nuclear layer retina that is most primary eye in children. The tumor tends to occur early childhood or infancy present at birth. majority are sporadic, but condition may be transmitted as autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS; STRABISMUS; visual loss represent common clinical characteristics this condition. (From DeVita et al., Cancer: Principles Practice Oncology, 5th ed, p2104)
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