\sˈʌbstɹe͡ɪt sˈa͡ɪklɪŋ], \sˈʌbstɹeɪt sˈaɪklɪŋ], \s_ˈʌ_b_s_t_ɹ_eɪ_t s_ˈaɪ_k_l_ɪ_ŋ]\
Definitions of SUBSTRATE CYCLING
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A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.
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