STRIATONIGRAL ATROPHY
\stɹˈa͡ɪɐtˌɒnɪɡɹə͡l ˈatɹəfi], \stɹˈaɪɐtˌɒnɪɡɹəl ˈatɹəfi], \s_t_ɹ_ˈaɪ__ɐ_t_ˌɒ_n_ɪ_ɡ_ɹ_əl ˈa_t_ɹ_ə_f_i]\
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A sporadic neurodegenerative disease with onset in middle-age characterized clinically by Parkinsonian features (e.g., MUSCLE RIGIDITY; HYPOKINESIA; stooped posture) and HYPOTENSION. This condition is considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Pathologic features include a prominent loss of neurons in the zona compacta of the SUBSTANTIA NIGRA and PUTAMEN. (From Adams et al., Principles of Neurology, 6th ed, p1075-6)
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Word of the day
tinctura quininae ammoniata
- A preparation made by dissolving quinin sulphate in alcohol [Br. Ph.].