STEM CELL FACTOR RECEPTOR
\stˈɛm sˈɛl fˈaktə ɹɪsˈɛptə], \stˈɛm sˈɛl fˈaktə ɹɪsˈɛptə], \s_t_ˈɛ_m s_ˈɛ_l f_ˈa_k_t_ə ɹ_ɪ_s_ˈɛ_p_t_ə]\
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A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEIN C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis. EC 2.7.11.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.