\stˌiːtəkɹɪptˈə͡ʊsɪs], \stˌiːtəkɹɪptˈə‍ʊsɪs], \s_t_ˌiː_t_ə_k_ɹ_ɪ_p_t_ˈəʊ_s_ɪ_s]\


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1920 - A practical medical dictionary.
By Stedman, Thomas Lathrop

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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