SPLEEN FOCUS FORMING VIRUSES
\splˈiːn fˈə͡ʊkəs fˈɔːmɪŋ vˈa͡ɪɹəsɪz], \splˈiːn fˈəʊkəs fˈɔːmɪŋ vˈaɪɹəsɪz], \s_p_l_ˈiː_n f_ˈəʊ_k_ə_s f_ˈɔː_m_ɪ_ŋ v_ˈaɪ_ɹ_ə_s_ɪ_z]\
Definitions of SPLEEN FOCUS FORMING VIRUSES
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Strains of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with other viral types.
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- A malignant arising nuclear layer retina that is most primary eye in children. The tumor tends to occur early childhood or infancy present at birth. majority are sporadic, but condition may be transmitted as autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS; STRABISMUS; visual loss represent common clinical characteristics this condition. (From DeVita et al., Cancer: Principles Practice Oncology, 5th ed, p2104)