SKELETAL EFFECT
\skˈɛlɪtə͡l ɪfˈɛkt], \skˈɛlɪtəl ɪfˈɛkt], \s_k_ˈɛ_l_ɪ_t_əl ɪ_f_ˈɛ_k_t]\
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A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS, OSTEOCYTES and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydoxyapatite crystals form the BONE MATRIX.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.