SIMIAN T LYMPHOTROPIC VIRUS TYPE I
\sˈɪmi͡ən tˈiː lˌɪmfətɹˈɒpɪk vˈa͡ɪɹəs tˈa͡ɪp ˈa͡ɪ], \sˈɪmiən tˈiː lˌɪmfətɹˈɒpɪk vˈaɪɹəs tˈaɪp ˈaɪ], \s_ˈɪ_m_iə_n t_ˈiː l_ˌɪ_m_f_ə_t_ɹ_ˈɒ_p_ɪ_k v_ˈaɪ_ɹ_ə_s t_ˈaɪ_p ˈaɪ]\
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A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2, closely related to the human HTLV-1 virus. The clinical, hematological, and histopathological characteristics of the disease in STLV-infected monkeys are very similar to those of human adult T-cell leukemia. Subgroups include the African green monkey subtype (STLV-I-AGM), for which the nucleotide sequence is 95% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1, and the Asian rhesus macaque subtype (STLV-I-MM), for which the nucleotide sequence is 90% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.