SICK HEAD
\sˈɪk hˈɛd], \sˈɪk hˈɛd], \s_ˈɪ_k h_ˈɛ_d]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.