SELECTIVE ESTROGEN RECEPTOR MODULATORS
\sɪlˈɛktɪv ˈɛstɹəd͡ʒən ɹɪsˈɛptə mˈɒdjʊlˌe͡ɪtəz], \sɪlˈɛktɪv ˈɛstɹədʒən ɹɪsˈɛptə mˈɒdjʊlˌeɪtəz], \s_ɪ_l_ˈɛ_k_t_ɪ_v ˈɛ_s_t_ɹ_ə_dʒ_ə_n ɹ_ɪ_s_ˈɛ_p_t_ə m_ˈɒ_d_j_ʊ_l_ˌeɪ_t_ə_z]\
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A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate the estrogen receptor, but act as either an estrogen agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
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