S6 H4 KINASE
\ˈɛs sˈɪks ˈe͡ɪt͡ʃ fˈɔː kˈɪne͡ɪs], \ˈɛs sˈɪks ˈeɪtʃ fˈɔː kˈɪneɪs], \ˈɛ_s s_ˈɪ_k_s ˈeɪ_tʃ f_ˈɔː k_ˈɪ_n_eɪ_s]\
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A protein serine/threonine kinase which is involved in cell transformation by polyoma virus and is connected to the expression of IGF2. The immunosuppressant rapamycin inhibits the activation of the kinase, leading to reduced translation of certain mRNAs and a decrease in protein synthesis. EC 2.7.10.-.
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.