RX6029M
\ˌɑːɹˈɛks sˈɪks θˈa͡ʊzənd ən twˈɛntinˈa͡ɪn ˈɛm], \ˌɑːɹˈɛks sˈɪks θˈaʊzənd ən twˈɛntinˈaɪn ˈɛm], \ˌɑː_ɹ_ˈɛ_k_s s_ˈɪ_k_s θ_ˈaʊ_z_ə_n_d ə_n t_w_ˈɛ_n_t_i_n_ˈaɪ_n ˈɛ_m]\
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A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.