RO41284

\ɹˈə͡ʊ fˈɔːtiwˈɒn θˈa͡ʊzənd tˈuːhˈʌndɹədən ˈe͡ɪtifˈɔː], \ɹˈə‍ʊ fˈɔːtiwˈɒn θˈa‍ʊzənd tˈuːhˈʌndɹədən ˈe‍ɪtifˈɔː], \ɹ_ˈəʊ f_ˈɔː_t_i_w_ˈɒ_n θ_ˈaʊ_z_ə_n_d_ t_ˈuː_h_ˈʌ_n_d_ɹ_ə_d_ə_n ˈeɪ_t_i_f_ˈɔː]\

Definitions of RO41284

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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