RHIZOMELIC PSEUDOPOLYARTHRITIS
\ɹa͡ɪzˈə͡ʊmlɪk sˌuːdə͡ʊpˌɒlɪɑːθɹˈa͡ɪtɪs], \ɹaɪzˈəʊmlɪk sˌuːdəʊpˌɒlɪɑːθɹˈaɪtɪs], \ɹ_aɪ_z_ˈəʊ_m_l_ɪ_k s_ˌuː_d_əʊ_p_ˌɒ_l_ɪ__ɑː_θ_ɹ_ˈaɪ_t_ɪ_s]\
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A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with TEMPORAL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.