RETROLENTAL FIBROPLASIA
\ɹˌɛtɹə͡ʊlˈɛntə͡l fˌɪbɹəplˈe͡ɪzi͡ə], \ɹˌɛtɹəʊlˈɛntəl fˌɪbɹəplˈeɪziə], \ɹ_ˌɛ_t_ɹ_əʊ_l_ˈɛ_n_t_əl f_ˌɪ_b_ɹ_ə_p_l_ˈeɪ_z_iə]\
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A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.