RETROGRADING
\ɹˌɛtɹə͡ʊɡɹˈe͡ɪdɪŋ], \ɹˌɛtɹəʊɡɹˈeɪdɪŋ], \ɹ_ˌɛ_t_ɹ_əʊ_ɡ_ɹ_ˈeɪ_d_ɪ_ŋ]\
Definitions of RETROGRADING
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ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.