RESTRICTION MODIFICATION SYSTEMS
\ɹɪstɹˈɪkʃən mˌɒdɪfɪkˈe͡ɪʃən sˈɪstəmz], \ɹɪstɹˈɪkʃən mˌɒdɪfɪkˈeɪʃən sˈɪstəmz], \ɹ_ɪ_s_t_ɹ_ˈɪ_k_ʃ_ə_n m_ˌɒ_d_ɪ_f_ɪ_k_ˈeɪ_ʃ_ə_n s_ˈɪ_s_t_ə_m_z]\
Definitions of RESTRICTION MODIFICATION SYSTEMS
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Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
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Word of the day
- The act of interserting, or that which is interserted.