\ɹˌiːˈa͡ɪfnsta͡ɪnz sˈɪndɹə͡ʊm], \ɹˌiːˈaɪfnstaɪnz sˈɪndɹəʊm], \ɹ_ˌiː__ˈaɪ_f_n_s_t_aɪ_n_z s_ˈɪ_n_d_ɹ_əʊ_m]\
Definitions of REIFENSTEINS SYNDROME
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A familial form of PSEUDOHERMAPHRODITISM transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN; AR) gene. Severity of the defect in AR quantity or quality correlates with their phenotypes. The phenotype spectrum varies from those with normal female external genitalia in ANDROGEN-INSENSITIVITY SYNDROME, through those with genital ambiguity in Reifenstein Syndrome, to that of a normal male with INFERTILITY.
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