RADIATION FIBROSES
\ɹˌe͡ɪdɪˈe͡ɪʃən fˈɪbɹə͡ʊzɪz], \ɹˌeɪdɪˈeɪʃən fˈɪbɹəʊzɪz], \ɹ_ˌeɪ_d_ɪ__ˈeɪ_ʃ_ə_n f_ˈɪ_b_ɹ_əʊ_z_ɪ_z]\
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Injurious effects of radiotherapy on the lungs. There are three phases in the reaction of the lungs to radiation injury: an acute phase occurring 1 to 2 months after exposure, a subacute phase 2 to 9 months after exposure, and a chronic or fibrotic phase more than 9 months after exposure. In the acute phase there is vascular damage, congestion, edema, and mononuclear cell infiltration; in the subacute phase the alveolar walls are infiltrated with mononuclear inflammatory cells and fibroblasts; in the chronic phase, alveolar fibrosis and capillary sclerosis take place. (Cecil Textbook of Medicine, 19th ed, p2343)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.