QUINOLONE ANTIINFECTIVE AGENTS
\kwˈɪnəlˌə͡ʊn ˌantɪɪnfˈɛktɪv ˈe͡ɪd͡ʒənts], \kwˈɪnəlˌəʊn ˌantɪɪnfˈɛktɪv ˈeɪdʒənts], \k_w_ˈɪ_n_ə_l_ˌəʊ_n ˌa_n_t_ɪ__ɪ_n_f_ˈɛ_k_t_ɪ_v ˈeɪ_dʒ_ə_n_t_s]\
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A group of synthetic antimicrobial agents which usually contain a 4-quinolinone ring structure. A few compounds belonging to this group have related nitrogen heterocyclic ring structures such as naphthyridine or phthalazine groups. All compounds in this group are substituted with an oxo group at the 4-position. The second-generation quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine moiety at the 6-position. The quinolones inhibit the A subunit of DNA gyrase and thus interfere with the ability of the enzyme to repair bacterial DNA breaks during replication. The compounds have a broad spectrum of activity against a variety of aerobic bacteria.
By DataStellar Co., Ltd
Nearby Words
- quinolinic acid, strontium salt
- quinolinols
- quinolinones
- quinologist
- quinology
- Quinolone Antiinfective Agents
- quinolones
- quinomycin a
- quinon
- quinone
- quinone reductase