PROTAMINE SULFATE
\pɹˈə͡ʊtɐmˌiːn sˈʌlfe͡ɪt], \pɹˈəʊtɐmˌiːn sˈʌlfeɪt], \p_ɹ_ˈəʊ_t_ɐ_m_ˌiː_n s_ˈʌ_l_f_eɪ_t]\
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A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
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