PROLYL HYDROXYLASE
\pɹˈɒlɪl hˈa͡ɪdɹəksˌɪle͡ɪs], \pɹˈɒlɪl hˈaɪdɹəksˌɪleɪs], \p_ɹ_ˈɒ_l_ɪ_l h_ˈaɪ_d_ɹ_ə_k_s_ˌɪ_l_eɪ_s]\
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A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in protocollagen, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.