\pɹˈɒɡjuːˌanɪl], \pɹˈɒɡjuːˌanɪl], \p_ɹ_ˈɒ_ɡ_j_uː_ˌa_n_ɪ_l]\
Definitions of PROGUANIL
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A biguanide compound which has little antimalarial activity until metabolized in the body to the active antimalarial agent cycloguanil. The usefulness of proguanil is limited by the rapid development of drug resistance by the malarial parasite. The hydrochloride is used for the casual prophylaxis of falciparum malaria, to suppress other forms of malaria, and to reduce transmission of infection (From Martindale, The Extra Pharmacopoeia, 30th ed, p405)
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- A predisposition to interstitial subcutaneous serous or fibrinous infiltrations; subjects suffer from swollen lymph nodes, thickening of tongue, pruritus, seborrhea, gastric and cardiac crises; the condition is aggravated by pilocarpine, but favorably affected atropine adrenalin.