PROGRESSIVE SUPRANUCLEAR OPHTHALMOPLEGIAS
\pɹəɡɹˈɛsɪv sˈʌpɹɐnjˌuːkli͡əɹ ˌɒfθɐlməplˈiːd͡ʒəz], \pɹəɡɹˈɛsɪv sˈʌpɹɐnjˌuːkliəɹ ˌɒfθɐlməplˈiːdʒəz], \p_ɹ_ə_ɡ_ɹ_ˈɛ_s_ɪ_v s_ˈʌ_p_ɹ_ɐ_n_j_ˌuː_k_l_iə_ɹ ˌɒ_f_θ_ɐ_l_m_ə_p_l_ˈiː_dʒ_ə_z]\
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A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.
Nearby Words
- progressive processes
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- Progressive Supranuclear Ophthalmoplegias
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- progressive supranuclear palsy
- progressive tax
- progressive tense
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