PROGRESSIVE SUPRANUCLEAR OPHTHALMOPLEGIA
\pɹəɡɹˈɛsɪv sˈʌpɹɐnjˌuːkli͡əɹ ˌɒfθɐlməplˈiːd͡ʒə], \pɹəɡɹˈɛsɪv sˈʌpɹɐnjˌuːkliəɹ ˌɒfθɐlməplˈiːdʒə], \p_ɹ_ə_ɡ_ɹ_ˈɛ_s_ɪ_v s_ˈʌ_p_ɹ_ɐ_n_j_ˌuː_k_l_iə_ɹ ˌɒ_f_θ_ɐ_l_m_ə_p_l_ˈiː_dʒ_ə]\
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A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
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Nearby Words
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