PROGRAMMED CELL DEATHS
\pɹˈə͡ʊɡɹamd sˈɛl dˈɛθs], \pɹˈəʊɡɹamd sˈɛl dˈɛθs], \p_ɹ_ˈəʊ_ɡ_ɹ_a_m_d s_ˈɛ_l d_ˈɛ_θ_s]\
Definitions of PROGRAMMED CELL DEATHS
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One of the two mechanisms by which CELL DEATH occurs (the other being the pathological process of NECROSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
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