PRESENILE DEMENTIAS
\pɹɪsˈɛna͡ɪl dɪmˈɛnʃəz], \pɹɪsˈɛnaɪl dɪmˈɛnʃəz], \p_ɹ_ɪ_s_ˈɛ_n_aɪ_l d_ɪ_m_ˈɛ_n_ʃ_ə_z]\
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A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgement, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
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